15 Jan
15Jan

Vaccine efficacy is the percentage reduction of disease in a vaccinated group of people compared to an unvaccinated group, using the most favorable conditions. 

Originally designed and calculated by Greenwood and Yule in 1915 for the cholera and typhoid vaccines, vaccine efficacy is calculated and reflects the immune response efficiency in reducing infection and also stimulating the required immune response.

Initial reports on antibody levels post vaccination

WHO Definitions of efficacy in populations

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