MUSE (multilineage-differentiating stress-enduring) cells are a unique and promising subset of mesenchymal stem cells that have garnered attention in the field of regenerative medicine. Discovered in 2010, MUSE cells possess remarkable characteristics that set them apart from conventional stem cells. These cells can be derived from various sources, such as bone marrow and adipose tissue, and have the ability to differentiate into cells from multiple lineages, including those of the ectoderm, mesoderm, and endoderm. One of their most intriguing attributes is their resistance to stress and their capacity to self-renew, making them highly durable and potentially suitable for therapeutic applications in tissue repair and regeneration. The versatility and resilience of MUSE cells make them a compelling subject of ongoing research with the potential to revolutionize regenerative medicine and treat a variety of conditions.